MozartV1, PascalFrancis, Corpus, bibRecord, 000116

Overture for growth hormone : Requiem for interleukin-6?

Identifieur interne : 000116 ( PascalFrancis/Corpus ); précédent : 000115; suivant : 000117

Overture for growth hormone : Requiem for interleukin-6?

Auteurs : Claudius Conrad ; Hanno Niess ; Karl-Walter Jauch ; Christiane J. Bruns ; Wolfgang H. Hartl ; Lorenz Welker

Source :

Critical care medicine [ 0090-3493 ] ; 2007.

RBID : Pascal:08-0013275

Descripteurs français

Pascal (Inist)
- Réanimation, Soin intensif, Somatotropine, Interleukine 6, Unité soin intensif.

English descriptors

KwdEn :
- Intensive care, Intensive care unit, Interleukin 6, Resuscitation, Somatotropin.

Abstract

Background: Music has been used for therapeutic purposes since the beginning of cultural history. However, despite numerous descriptions of beneficial effects, the precise mechanisms by which music may improve human well-being remain unclear. Methods: We conducted a randomized study in ten critically ill patients to identify mechanisms of music-induced relaxation using a special selection of slow movements of Mozart's piano sonatas. These sonatas were analyzed for compositional elements of relaxation. We measured circulatory variables, brain electrical activity, serum levels of stress hormones and cytokines, requirements for sedative drugs, and level of sedation before and at the end of a 1-hr therapeutic session. Results: Compared with controls, we found that music application significantly reduced the amount of sedative drugs needed to achieve a comparable degree of sedation. Simultaneously, among those receiving the music intervention, plasma concentrations of growth hormone increased, whereas those of interleukin-6 and epinephrine decreased. The reduction in systemic stress hormone levels was associated with a significantly lower blood pressure and heart rate. Conclusion: Based on the effects of slow movements of Mozart's piano sonatas, we propose a neurohumoral pathway by which music might exert its sedative action. This model includes an interaction of the hypothalamic-pituitary axis with the adrenal medulla via mediators of the unspecific immune system.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 0090-3493`
A02	`01`			`@0 CCMDC7`
A03		`1`		`@0 Crit. care med.`
A05				`@2 35`
A06				`@2 12`
A08	`01`	`1`	`ENG`	`@1 Overture for growth hormone : Requiem for interleukin-6?`
A11	`01`	`1`		`@1 CONRAD (Claudius)`
A11	`02`	`1`		`@1 NIESS (Hanno)`
A11	`03`	`1`		`@1 JAUCH (Karl-Walter)`
A11	`04`	`1`		`@1 BRUNS (Christiane J.)`
A11	`05`	`1`		`@1 HARTL (Wolfgang H.)`
A11	`06`	`1`		`@1 WELKER (Lorenz)`
A14	`01`			`@1 Department of Surgery, Massachusetts General Hospital @2 Boston, MA @3 USA @Z 1 aut.`
A14	`02`			`@1 Department of Surgery, University of Munich-Grosshadern @2 Munich @3 DEU @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut.`
A14	`03`			`@1 Department of Fine Arts, Institute of Music Science, University of Munich @2 Munich @3 DEU @Z 6 aut.`
A20				`@1 2709-2713`
A21				`@1 2007`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 17751 @5 354000162159240050`
A44				`@0 0000 @1 © 2008 INIST-CNRS. All rights reserved.`
A45				`@0 49 ref.`
A47	`01`	`1`		`@0 08-0013275`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Critical care medicine`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 Background: Music has been used for therapeutic purposes since the beginning of cultural history. However, despite numerous descriptions of beneficial effects, the precise mechanisms by which music may improve human well-being remain unclear. Methods: We conducted a randomized study in ten critically ill patients to identify mechanisms of music-induced relaxation using a special selection of slow movements of Mozart's piano sonatas. These sonatas were analyzed for compositional elements of relaxation. We measured circulatory variables, brain electrical activity, serum levels of stress hormones and cytokines, requirements for sedative drugs, and level of sedation before and at the end of a 1-hr therapeutic session. Results: Compared with controls, we found that music application significantly reduced the amount of sedative drugs needed to achieve a comparable degree of sedation. Simultaneously, among those receiving the music intervention, plasma concentrations of growth hormone increased, whereas those of interleukin-6 and epinephrine decreased. The reduction in systemic stress hormone levels was associated with a significantly lower blood pressure and heart rate. Conclusion: Based on the effects of slow movements of Mozart's piano sonatas, we propose a neurohumoral pathway by which music might exert its sedative action. This model includes an interaction of the hypothalamic-pituitary axis with the adrenal medulla via mediators of the unspecific immune system.
C02	`01`	`X`		`@0 002B27B`
C02	`02`	`X`		`@0 002B24O06`
C02	`03`	`X`		`@0 002A28A02`
C03	`01`	`X`	`FRE`	`@0 Réanimation @5 09`
C03	`01`	`X`	`ENG`	`@0 Resuscitation @5 09`
C03	`01`	`X`	`SPA`	`@0 Reanimación @5 09`
C03	`02`	`X`	`FRE`	`@0 Soin intensif @5 10`
C03	`02`	`X`	`ENG`	`@0 Intensive care @5 10`
C03	`02`	`X`	`SPA`	`@0 Cuidado intensivo @5 10`
C03	`03`	`X`	`FRE`	`@0 Somatotropine @5 11`
C03	`03`	`X`	`ENG`	`@0 Somatotropin @5 11`
C03	`03`	`X`	`SPA`	`@0 Somatotropina @5 11`
C03	`04`	`X`	`FRE`	`@0 Interleukine 6 @5 12`
C03	`04`	`X`	`ENG`	`@0 Interleukin 6 @5 12`
C03	`04`	`X`	`SPA`	`@0 Interleuquina 6 @5 12`
C03	`05`	`X`	`FRE`	`@0 Unité soin intensif @5 13`
C03	`05`	`X`	`ENG`	`@0 Intensive care unit @5 13`
C03	`05`	`X`	`SPA`	`@0 Unidad terapia intensiva @5 13`
C07	`01`	`X`	`FRE`	`@0 Hormone adénohypophysaire @5 37`
C07	`01`	`X`	`ENG`	`@0 Adenohypophyseal hormone @5 37`
C07	`01`	`X`	`SPA`	`@0 Hormona adenohipofisaria @5 37`
C07	`02`	`X`	`FRE`	`@0 Cytokine @5 38`
C07	`02`	`X`	`ENG`	`@0 Cytokine @5 38`
C07	`02`	`X`	`SPA`	`@0 Citoquina @5 38`
N21				`@1 009`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 08-0013275 INIST
ET :	Overture for growth hormone : Requiem for interleukin-6?
AU :	CONRAD (Claudius); NIESS (Hanno); JAUCH (Karl-Walter); BRUNS (Christiane J.); HARTL (Wolfgang H.); WELKER (Lorenz)
AF :	Department of Surgery, Massachusetts General Hospital/Boston, MA/Etats-Unis (1 aut.); Department of Surgery, University of Munich-Grosshadern/Munich/Allemagne (2 aut., 3 aut., 4 aut., 5 aut.); Department of Fine Arts, Institute of Music Science, University of Munich/Munich/Allemagne (6 aut.)
DT :	Publication en série; Niveau analytique
SO :	Critical care medicine; ISSN 0090-3493; Coden CCMDC7; Etats-Unis; Da. 2007; Vol. 35; No. 12; Pp. 2709-2713; Bibl. 49 ref.
LA :	Anglais
EA :	Background: Music has been used for therapeutic purposes since the beginning of cultural history. However, despite numerous descriptions of beneficial effects, the precise mechanisms by which music may improve human well-being remain unclear. Methods: We conducted a randomized study in ten critically ill patients to identify mechanisms of music-induced relaxation using a special selection of slow movements of Mozart's piano sonatas. These sonatas were analyzed for compositional elements of relaxation. We measured circulatory variables, brain electrical activity, serum levels of stress hormones and cytokines, requirements for sedative drugs, and level of sedation before and at the end of a 1-hr therapeutic session. Results: Compared with controls, we found that music application significantly reduced the amount of sedative drugs needed to achieve a comparable degree of sedation. Simultaneously, among those receiving the music intervention, plasma concentrations of growth hormone increased, whereas those of interleukin-6 and epinephrine decreased. The reduction in systemic stress hormone levels was associated with a significantly lower blood pressure and heart rate. Conclusion: Based on the effects of slow movements of Mozart's piano sonatas, we propose a neurohumoral pathway by which music might exert its sedative action. This model includes an interaction of the hypothalamic-pituitary axis with the adrenal medulla via mediators of the unspecific immune system.
CC :	002B27B; 002B24O06; 002A28A02
FD :	Réanimation; Soin intensif; Somatotropine; Interleukine 6; Unité soin intensif
FG :	Hormone adénohypophysaire; Cytokine
ED :	Resuscitation; Intensive care; Somatotropin; Interleukin 6; Intensive care unit
EG :	Adenohypophyseal hormone; Cytokine
SD :	Reanimación; Cuidado intensivo; Somatotropina; Interleuquina 6; Unidad terapia intensiva
LO :	INIST-17751.354000162159240050
ID :	08-0013275

Links to Exploration step

Pascal:08-0013275

Le document en format XML

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<front><div type="abstract" xml:lang="en">Background: Music has been used for therapeutic purposes since the beginning of cultural history. However, despite numerous descriptions of beneficial effects, the precise mechanisms by which music may improve human well-being remain unclear. Methods: We conducted a randomized study in ten critically ill patients to identify mechanisms of music-induced relaxation using a special selection of slow movements of Mozart's piano sonatas. These sonatas were analyzed for compositional elements of relaxation. We measured circulatory variables, brain electrical activity, serum levels of stress hormones and cytokines, requirements for sedative drugs, and level of sedation before and at the end of a 1-hr therapeutic session. Results: Compared with controls, we found that music application significantly reduced the amount of sedative drugs needed to achieve a comparable degree of sedation. Simultaneously, among those receiving the music intervention, plasma concentrations of growth hormone increased, whereas those of interleukin-6 and epinephrine decreased. The reduction in systemic stress hormone levels was associated with a significantly lower blood pressure and heart rate. Conclusion: Based on the effects of slow movements of Mozart's piano sonatas, we propose a neurohumoral pathway by which music might exert its sedative action. This model includes an interaction of the hypothalamic-pituitary axis with the adrenal medulla via mediators of the unspecific immune system.</div>
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<fC07 i1="02" i2="X" l="ENG"><s0>Cytokine</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Citoquina</s0>
<s5>38</s5>
</fC07>
<fN21><s1>009</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
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<server><NO>PASCAL 08-0013275 INIST</NO>
<ET>Overture for growth hormone : Requiem for interleukin-6?</ET>
<AU>CONRAD (Claudius); NIESS (Hanno); JAUCH (Karl-Walter); BRUNS (Christiane J.); HARTL (Wolfgang H.); WELKER (Lorenz)</AU>
<AF>Department of Surgery, Massachusetts General Hospital/Boston, MA/Etats-Unis (1 aut.); Department of Surgery, University of Munich-Grosshadern/Munich/Allemagne (2 aut., 3 aut., 4 aut., 5 aut.); Department of Fine Arts, Institute of Music Science, University of Munich/Munich/Allemagne (6 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Critical care medicine; ISSN 0090-3493; Coden CCMDC7; Etats-Unis; Da. 2007; Vol. 35; No. 12; Pp. 2709-2713; Bibl. 49 ref.</SO>
<LA>Anglais</LA>
<EA>Background: Music has been used for therapeutic purposes since the beginning of cultural history. However, despite numerous descriptions of beneficial effects, the precise mechanisms by which music may improve human well-being remain unclear. Methods: We conducted a randomized study in ten critically ill patients to identify mechanisms of music-induced relaxation using a special selection of slow movements of Mozart's piano sonatas. These sonatas were analyzed for compositional elements of relaxation. We measured circulatory variables, brain electrical activity, serum levels of stress hormones and cytokines, requirements for sedative drugs, and level of sedation before and at the end of a 1-hr therapeutic session. Results: Compared with controls, we found that music application significantly reduced the amount of sedative drugs needed to achieve a comparable degree of sedation. Simultaneously, among those receiving the music intervention, plasma concentrations of growth hormone increased, whereas those of interleukin-6 and epinephrine decreased. The reduction in systemic stress hormone levels was associated with a significantly lower blood pressure and heart rate. Conclusion: Based on the effects of slow movements of Mozart's piano sonatas, we propose a neurohumoral pathway by which music might exert its sedative action. This model includes an interaction of the hypothalamic-pituitary axis with the adrenal medulla via mediators of the unspecific immune system.</EA>
<CC>002B27B; 002B24O06; 002A28A02</CC>
<FD>Réanimation; Soin intensif; Somatotropine; Interleukine 6; Unité soin intensif</FD>
<FG>Hormone adénohypophysaire; Cytokine</FG>
<ED>Resuscitation; Intensive care; Somatotropin; Interleukin 6; Intensive care unit</ED>
<EG>Adenohypophyseal hormone; Cytokine</EG>
<SD>Reanimación; Cuidado intensivo; Somatotropina; Interleuquina 6; Unidad terapia intensiva</SD>
<LO>INIST-17751.354000162159240050</LO>
<ID>08-0013275</ID>
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Overture for growth hormone : Requiem for interleukin-6?

Overture for growth hormone : Requiem for interleukin-6?

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